THE EFFECT OF XUEFU ZHUYU DECOCTION ON ATTENUATION OF THE ATHEROSCLEROSIS IN THE RATS WITH ATHEROSCLEROSIS

To study the effect of Xuefu Zhuyu decoction on attenuation of the atherosclerosis in the rats with atherosclerosis.Forty Sprague Dawley rats were divided randomly into groups of 8 rats each,control group,model group,and three treatment groups(Xue Zhi Kang group,high dose Xuefu Zhuyu decoction group,and low dose Xuefu Zhuyu decoction group).The control group was fed with normal diet,model group a high-fat diet,treatment groups the high fat diet mixed with Xue Zhi Kang,High dose and low dose Xuefu Zhuyu decoction respectively.After 12 weeks,treatment,the morphological characteristics(HE stain and ultrastructure) of the aorta were observsed,the blood were taken from the abdominal aorta,and the blood levels of cholesterol(TC),triglycerides(TG),low-density lipoprotein(LDL-c),and high-density lipoprotein(HDL-c) were detected later.It was found that the aortic morphological changes of both the high and dose Xuefu Zhuyu decoction group are lighter than that of model group.The Xuefu Zhuyu decoction groups could significantly decrease the blood level of TC,TG,and LDL-c,increasing that of HDL-c(P0.01).So Xuefu Zhuyu decoction can attenuate the atherosclerosis effectively,whose pathogenesis might be related with its adjusting role on the blood level of lipid.