2011•Journal of Henan UniversityRequires access

α-Glucosidase inhibitory activity of extracts from Saururus chinensis(Lour.) Baill

Wenyi Kang

Abstract

Objective: To study the α-glucosidase inhibitory activity of extracts from Saururus chinensis(Lour.) Baill.Methods: By establishing α-glucosidase inhibitory model in vitro,the activity of extracts from S.Chinensis was screened.The relationship of inhibitory ratio with the extract concentration was also studied.Results: The extracts from S.Chinensis showed good inhibitory activity onα-Glucosidase.The ethyl acetate from S.Chinensis had the highest inhibitor activity(IC50=122.7 mg/L),and the next ones were petroleum ether and n-butanol ether(IC50 =203.3 mg/L、IC50=659.9 mg/L).Three extracts of S.Chinensis(Lour.) Baill showed higher activity than that of Acarbose(IC50=1 103.01 mg/L).Conclusion: The extracts from S.Chinensis had good inhibitory activity on αglucosidase.

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Key concepts: Acarbose, Petroleum ether, Traditional medicine, Ethyl acetate, IC50, Chemistry, Alpha-glucosidase, Inhibitory postsynaptic potential