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2013•Dalian Gongye Daxue xuebaoRequires access

Inhibitory activities of extracts from Cinnamomum cassia on α-glucosidase

Wei Xiao

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Abstract

The inhibitory activities of different polar solvent extracts from Cortex Cinnamomi on α-glucosidase were assayed in vitro.The results showed that all these extracts had different inhibitory activity against α-glucosidase,and the n-BuOH extract had the highest inhibitory activity on α-glucosidase(IC50=83.10 μg/mL),which was more lower than that of Acarbose(IC50=572.76 μg/mL).The inhibitory kinetic of n-BuOH extract was investigated,and the inhabitory type was anticompetitive(Ki=53.75 μg/mL).

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What this paper is about

The inhibitory activities of different polar solvent extracts from Cortex Cinnamomi on α-glucosidase were assayed in vitro.The results showed that all these extracts had different inhibitory activity against α-glucosidase,and the n-BuOH extract had the highest inhibitory activity on α-glucosidase(IC50=83.10 μg/mL),which was more lower than that of Acarbose(IC50=572.76 μg/mL).The inhibitory kinetic of n-BuOH extract was investigated,and the inhabitory type was anticompetitive(Ki=53.75 μg/mL).

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Available abstract

The inhibitory activities of different polar solvent extracts from Cortex Cinnamomi on α-glucosidase were assayed in vitro.The results showed that all these extracts had different inhibitory activity against α-glucosidase,and the n-BuOH extract had the highest inhibitory activity on α-glucosidase(IC50=83.10 μg/mL),which was more lower than that of Acarbose(IC50=572.76 μg/mL).The inhibitory kinetic of n-BuOH extract was investigated,and the inhabitory type was anticompetitive(Ki=53.75 μg/mL).

Key concepts: Acarbose, Cinnamomum, IC50, Cassia, Inhibitory postsynaptic potential, Chemistry, Traditional medicine, In vitro

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