Effects of Ginkgo biloba leaf extract and diphyridamole injection on concentration of plasma oxidized low density liporotein in patients with acute brain infarction

AIM:To observe the effects of Ginkgo biloba leaf extract and diphyridamole injection on the levels of plasma oxidized low density liporotein (OX-LDL), superoxide dismutase (SOD), and malondialdehyde (MDA) in patients with acute cerebral infarction. METHODS: Seventy-two patients with acute brain infarction were divided into treatment group (treated with Ginkgo biloba leaf extract and diphyridamole injection, 20 mL, iv, gtt, qd, n = 36) and control group (treated with Danxiang Guanxin injection, 20 mL, iv, gtt, qd, n = 36). All the patients were treated for 14 d. The levels of plasma OX-LDL, SOD, and MDA were tested before and after treatment. RESULTS; In treatment group the levels of plasma OX-LDL, SOD, MDA before treatment were (0.69±s 0.20) mg·L-1, (80±6) kU·L-1, (6.4±1.3)μmoL·L-1, and those after treatment were (0.54±0.23) mg·L-1, (107±9) kU·L-1, (4.1±1.0)μmoL·L-1, resulting with a great difference between them (P 0.01). No significant statistical differences were found in the above mentioned assessment indexes in control group before and aftert treatment (P 0.05) . No remarkable adverse reactions occurred during this study in both groups. CONCLUSION: Ginkgo biloba leaf extract and diphyridamole injection can effectively clear out the free radicals and decrease the level of the plasma OX-LDL.