Effect of Ginkgo biloba Extract on Blood Pressure and Lipid Peroxidation of Target-organ in Renal Hypertension Rats

Objective:To study the effects of Ginkgo biloba extract on renal hypertension rats(RHR).The serum nitric oxide(NO) content and the content of superoxide dismutase(SOD),maleic disldehyde(MDA) in heart,brain and kidney tissue were investigated.Method:With the method of 2K1C,RHR were established and then the RHR were divided into five groups based on their blood pressure:blank group,model group,G.biloba extract high,middle,low dosage group and captopril group(n = 8,each).Systolic blood pressure(SBP) and diastolic blood pressure(DBP) were measured respectively before therapy and two weeks,four weeks,six weeks,eight weeks after therapy.The serum content of NO and MDA,SOD in heart,brain and kidney were measured after eight weeks of therapy.Result:After eight weeks treatment,G.biloba extract significantly declined the pressure of RHR.captopril group and G.biloba extract high group had no significant difference.The two groups both increased the serum of NO and SOD in heart,brain and kidney,declined the MDA.Conclusion: The anti-hypertensive function of G.biloba extract may be related to NO,and protect target organ via antioxidation.