The effect of ginkgo biloba extract injection on concentration of plasma oxidized low density lipoprotein in the patients with acute brain infarction

Objective To observe the effect of ginkgo biloba extract injection on the levels of plasma oxidized low density lipoprotein(OX-LDL),superoxide dismutase(SOD),and malondialdehyde(MDA) inthe patients with acute braininfarction.Methods 60patients with acute brain infarction were divided into a treatment group(treated with ginkgo biloba extract injection,20 ml,iv,gtt,qd,n=30) and a control group(treated with Xiangdan injection,20 ml,iv,gtt,qd,n=30).All the patients were treated for 14 d.The levels of plasma OX-LDL,SOD,and MDA were tested before and after treatment.Results In the treatment group,the levels of plasma OX-LDL,SOD,MDA before treatment were(0.70±0.19)mg/L,(81.0±8.0)kU/L,(6.6±1.3) mol/L,and those after treatment were(0.52±0.26)mg/L,(106.0±6.0)kU/L,(4.2 ±1.2) μmol/L,resulting with a great difference between them(P0.01).No significant statistical differences were found in the above mentioned assessment indexes in the control group before and after treatment(P0.05).No remarkable adverse reactions occurred during this study in both groups.Conclusion Ginkgo biloba extract injection can effectively clear out the free radicals and decrease the level of plasma OX-LDL.