Relationship between Serum Inflammatory Cytokines and Acute Coronary Syndrome

Objective:To investigate the role of serum inflammatory cytokines in the development of acute coronary syndrome(ACS).Methods:All of enrolled patients were diagnosed by clinical and coronary angiographic features and divided into four groups, the acute myocardial infarction(AMI) group, unstable angina pectoris(UAP) group, stable angina pectoris(SAP) group and control group.The values of high-sersitivity C-reactive protein(hs-CRP), matrix metallopeptidase 9(MMP-9) and tumor necrosis factor-α(TNF-α) in serum were measured by cytokine detection equipment system(BIO-RAD Biological Technology Co.Ltd, USA) and analysed in four groups with statistics.Results:Compared with SAP and the control groups, the levels of TNF-α and MMP-9 were increased significantly in AMI group(P 0.01).The level of serum hs-CRP was significantly higher in AMI group than that in UAP, SAP and control groups(P 0.05).There were no differences in the levels of hs-CRP and MMP-9 between UAP, SAP and control groups(P 0.05).It was found that there was positive relation between hs-CRP, MMP-9 and TNF-α by Pearson correlation analysis.Conclusion:There was obvious relation between coronary heart disease and inflammation.The cytokines characterized by the increases of hs-CRP, TNF-α and MMP-9 were involved in the formation and progression of atherosclerosis and served as markers of unstable plagues.