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Relationship between the expressions of CD44H,p-selectin and VEGF and the metastasis with lymph node in esophageal squamous cell carcinoma

Li Na

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Abstract

Objective To investigate the relationship of expressions of CD44H,P-selectin and VEGF and lymph node metastasis in patients with esophageal squamous cell carcinoma.Methods Immunohistochemical staining(SP method) was used to detect the expressions of CD44H,P-selectin and VEGF in 60 cases of esophageal carcinoma.Results CD44H,P-selectin and VEGF expressed highly in group with lymph node metastasis. There was a significant difference between the group with and without lymph node metastasis in esophageal squamous cell carcinoma(P0.05).The expression of P-selectin was positively correlated with the expression of VEGF in group with lymph node metastasis(P0.05).Conclusion It is closely correlated between the expressions of CD44H,P-selectin and VEGF,and metastasis with lymph node in esophageal squamous cell carcinoma,which might be served as biologic markers for assessment of the prognosis of esophageal carcinoma.

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What this paper is about

Objective To investigate the relationship of expressions of CD44H,P-selectin and VEGF and lymph node metastasis in patients with esophageal squamous cell carcinoma.Methods Immunohistochemical staining(SP method) was used to detect the expressions of CD44H,P-selectin and VEGF in 60 cases of esophageal carcinoma.Results CD44H,P-selectin and VEGF expressed highly in group with lymph node metastasis. There was a significant difference between the group with and without lymph node metastasis in esophageal squamous cell carcinoma(P0.05).The expression of P-selectin was positively correlated with the expression of VEGF in group with lymph node metastasis(P0.05).Conclusion It is closely correlated between the expressions of CD44H,P-selectin and VEGF,and metastasis with lymph node in esophageal squamous cell carcinoma,which might be served as biologic markers for assessment of the prognosis of esophageal carcinoma.

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Available abstract

Objective To investigate the relationship of expressions of CD44H,P-selectin and VEGF and lymph node metastasis in patients with esophageal squamous cell carcinoma.Methods Immunohistochemical staining(SP method) was used to detect the expressions of CD44H,P-selectin and VEGF in 60 cases of esophageal carcinoma.Results CD44H,P-selectin and VEGF expressed highly in group with lymph node metastasis. There was a significant difference between the group with and without lymph node metastasis in esophageal squamous cell carcinoma(P0.05).The expression of P-selectin was positively correlated with the expression of VEGF in group with lymph node metastasis(P0.05).Conclusion It is closely correlated between the expressions of CD44H,P-selectin and VEGF,and metastasis with lymph node in esophageal squamous cell carcinoma,which might be served as biologic markers for assessment of the prognosis of esophageal carcinoma.

Key concepts: Esophageal squamous cell carcinoma, VEGF receptors, Lymph node metastasis, Immunohistochemistry, Metastasis, Medicine, Lymph node, Carcinoma

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Relationship between the expressions of CD44H,p-selectin and VEGF and the metastasis with lymph node in esophageal squamous cell carcinoma — Research Paper | ScholarLens