Value of combined detection of CA125,CA19-9,CEA and AFP in diagnosis of ovarian cancer

Objective To discuss the value of combined detection of CA125,CA199,CEA and AFP in the diagnosis of ovarian cancer.Methods With chemiluminescence assay,serum levels of CA125,CA199,carcinoembryonic antigen(CEA)and alpha fetal protein(AFP)were detected in 42 patients with ovarian cancer(group A),51patients with benign ovarian tumors(group B)and 32 healthy woman volunteers(group C).The diagnostic specificity and sensitivity were compared.Results Serum levels of CA125and CA19-9were significantly higher in group A than those in groups of B and C(P0.05),which of CEA and AFP in group A had a rising trend compared to groups of B and C.The specificity,sensitivity and accuracy rate for the diagnosis were 92.31%,88.67% and 88.67%,respectively,when combined detection of above four remarkers,which were significantly higher than those reported by single assay(P0.05).Conclusion Combined detection of CA125,CA199,CEA and AFP can improve the specificity and sensitivity of diagnosing ovarian cancer.