The effect of repeated hemoperfusion on the cytokines in treatment of the patients with acute severe organophosphorus pesticide poisoning

Objective To assess the efficacy of the hemoperfusion in the treatment of the patients with acute severe organophosphorus pesticide poisoning.Methods Sixty patients with acute severe organophosphorus pesticide poisoning were enrolled and divided into hemoperfusion group(HP group) and non-hemoperfusion group(non-HP group),the non-HP group only accepted traditional treatment including gastric lavage,catharsis,emetic,atropine and pralidoxime,HP group were treated with both HP and traditional treatment at the same time.Observe all the patient′ duration of the recovery of CHE activity,the incidence of intermediate syndrome(IMS),the cumulative dosages of atropine in the hospital,the mortality,the day in hospital,the time of coma and cytokine TNF-α、IL-6、IL-10、IL-1β、hs-CRP between HP-group and non-HP group.Results The HP groups′ duration of the recovery of CHE activity,the incidence of intermediate syndrome(IMS),the cumulative dosages of atropine in the hospital,the day in hospital,the time of coma,the mortality was lower than those of the Non-HP group.Cytokine TNF-α,IL-6,IL-10,IL-1β,hs-CRP of HP-group were lower than those of non-HP group(P0.05 or P0.01).Conclusion Hemoperfusion is effective in the treatment of acute severe organophosphorus pesticide poisoning.Hemoperfusion can clear up some cytokines and protect the organ injury caused by organophosphorus pesticide poisoning.