Clinical Research on the Effect of Hemoperfusion on the Cytokines in Treatment of the Patients with Acute Severe Organophosphorus Pesticide Poisoning

Objective To assess the efficacy of the hemoperfusion in the treatment of the patients with acute severe organophosphorus pesticide poisoning.Methods Sixty patients with acute severe organophosphorus pesticide poisoning were enrolled and divided into hemoperfusion group(HP group) and non-hemoperfusion group(non-HP group),the non-HP group only accepted traditional treatment including gastric lavage,catharsis,emetic,atropine and pralidoxime chloride,HP group were treated with both HP and traditional treatment at the same time.Observe all the patient'cytokine TNF-α、IL-6、IL-10、IL-1β、hs-CRP between HP-group and non-HP group.Results The HP groups'cytokine TNF-α、 IL-6、IL-10、IL-1β,hs-CRP of HP-group were lower than those of non-HP group(P0.05).Conclusion Hemoperfusion can clear up some cytokines and protect the organ injury caused by organophosphorus pesticide poisoning.