Efficacy of hemoperfusion in treatment of acute severe organophosphorus pesticide poisoning

Objective To evaluate the efficacy of the hemoperfusion in the treatment of the patients with acute severe organophosphorus pesticide poisoning.Methods 49 patients with acute severe organophosphorus pesticide poisoning were divided into hemoperfusion group(HP group) and non-hemoperfusion group(control group).The control group only accepted traditional treatment including gastric lavage,catharsis,emetic,atropine andpralidoxime.HP group were treated with HP in addition to the above traditional treatments at the same time.The curative rate,the cumulative dosage of atropine,average hospitalization days and cholinesterase(CHE) activity were compared between two groups.Results The cumulative dosage of atropine and average hospitalization days in the control group were significantly higher than HP group′s(P0.01),though there was no obvious difference about the cure rate between the two groups.CHE activity determined after the first HP were significantly higher than the control group's at the same time(P0.01).Although CHE activity were obviously upregulated after HP within 48 hours,the range of upregulated CHE activities was highest within 24 hours.Conclusion Hemoperfusion is effective in the treatment of acute severe organophosphorus pesticide poisoning.