The correlation research among the polymorphisms of COMT gene,CYP 1A1 gene and Parkinson disease in Xinjiang

Objective To explore the independent and synergic role between the polymorphisms of catechol-o-methyltransferase(COMT) gene G1947A and cytochrome P4501A1(CYP1A1) gene Msp I in genetic susceptibility to Parkinson disease(PD) in Xinjiang region. Methods The polymorphisms of COMT gene and CYP1A1 gene was determined by polymerase chain-reaction restriction fragment length polymorphism(PCR-RFLP) in 237 idiopathic PD patients and 247 health controls in Xinjiang region. Results(1) There is no statistical difference in the distribution of the polymorphism of COMT gene and CYP1A1 gene between PD group and control group(all P 0. 05). stratified by nationality,gender and age,there is no statistical difference with the distribution of the polymorphism of both gene between each subgroup of PD group and control group(all P 0. 05).(2) Synergistic effect of G / G genotype of COMT gene and T / T genotype of CYP1A1 gene was associated with a 3. 288-fold increased relative risk of PD of Uygurs in Xinjiang(OR = 3. 288).(3) Synergistic effect of G / G genotype of COMT gene and T / C genotype of CYP1A1 gene was separately associated with a 0. 245-fold and 0. 451-fold decreased relative risk of PD of Uygurs and age≥60 years old people in Xinjiang(Uygurs: OR = 0. 245、age ≥60 years old: OR = 0. 451). Conclusion The synergistic function of the polymorphism of COMT gene and CYP1A1 gene might be increase or decrease the risk of PD of some population in Xinjiang region.