Relationship between gene polymorphisms of estrogen metabolic enzymes-CYP17 and CYP1A2 and the susceptibility of hysteromyoma

Objective:To explore the relationship between gene polymorphisms of CYP17 and CYP1A2 who participate in the synthesis and metabolism of estrogen and the occurrence of hysteromyoma in Chengdu. Methods:PCR-RFLP was used to analyze T-C polymorphism in CYP17 gene promoter region and G-A polymorphism in 2964 locus of CYP1A2 gene in 100 patients with hysteromyoma and 100 cases in control group. Results:T-C polymorphism of CYP17 gene existed in the two groups,but there was no significant difference in the frequencies of TT genotype,TC genotype and CC genotype,T allele and C allele between the two groups(P0.05);G-A polymorphism of CYP1A2 gene existed in the two groups,but there was no significant difference in the frequencies of GG genotype,GA genotype and AA genotype,G allele and A allele(P0.05). Conclusion:There is no correlation between T-C polymorphism in CYP17 gene promoter region,G-A polymorphism in 2964 locus of CYP1A2 gene and the risk of occurrence of hysteromyoma in Chengdu.