2012•Chinese Journal of Laboratory DiagnosisRequires access

Study on the correlation between gene polymorphism of COMT and endometriosis

Qu Yin

Abstract

Objective To explore the correlation between gene polymorphism of Catechol-O-Methyltransferase(COMT) and endometriosis(EMs).Methods Polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP) was used to analyze the polymorphism of COMT gene in 120 patients with endometriosis(59 with adenomyosis) and 65 healthy controls.Results There was no significant difference of the frequence of A allele and the distribution of genotype between EMs group and control group.The relative risk suffered from endometriosis of G/A and A/A genotype was 0.516(0.185-1.441) and 0.450(0.165-1.232) times of the G/G genotype respectively.Conclusion There was no correlation between the Met gene polymorphism of COMT and endometriosis.

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Key concepts: Endometriosis, Genotype, Adenomyosis, Catechol-O-methyl transferase, Restriction fragment length polymorphism, Correlation, Gene polymorphism, Polymorphism (computer science)