Preparation of Long-Circulating Praziquantel Liposome and Its Quality Evaluation

Based on the method of measuring content of baicalin, the coated rate,shape and diameter of microparticles,and distribution of baicalin were examined by microscope and laser light scattering.Then the preparation of liposome,kinds of surfactants,through single factor analysis and the main influencing factors were identified.At last,the optimized formula composition and technique of preparation were obtained by orthogonal design,and long-circulating praziquantel liposome was prepared.It was showed that the average diameter of the liposome optimized was 200 nm-300 nm with the coated rate above 72%.The liposome prepared with the procedure above had good encapsulation efficiency, and the preparation was simple,feasible and replicable.