ScholarLens Back to search
2010•Huaxi yaoxue zazhiRequires access

Preparation and evaluation of CA4 liposome

HE Ying-ju

Open publisher page 0 citations

Abstract

OBJECTIVE To study the formulation of CA4 liposome and evaluate its quality.METHODS Liposome was prepared with ether injection method by using the orthogonal design to screen the formulation.Its shape and particle sizes were determined by electronic microscopy and Zetamaster.The encapsulation efficiencies were determined by HPLC.The release behavior of the liposome were evaluated.RESULTS The average size was about 16.04 nm.The optimal preparation conditions of CA4 liposome were as follows: soybean phosphatidylcholine: cholesterol was 6∶1.The dosage of P,A,B were 2% ,2% and 20%.The average encapsulation efficiency of the liposome was 92.78%.Its in vitro release profile accorded with Higuchi model.CONCLUSION It is a practically acceptable formulation by ether injection method.

About this research paper

What this paper is about

OBJECTIVE To study the formulation of CA4 liposome and evaluate its quality.METHODS Liposome was prepared with ether injection method by using the orthogonal design to screen the formulation.Its shape and particle sizes were determined by electronic microscopy and Zetamaster.The encapsulation efficiencies were determined by HPLC.The release behavior of the liposome were evaluated.RESULTS The average size was about 16.04 nm.The optimal preparation conditions of CA4 liposome were as follows: soybean phosphatidylcholine: cholesterol was 6∶1.The dosage of P,A,B were 2% ,2% and 20%.The average encapsulation efficiency of the liposome was 92.78%.Its in vitro release profile accorded with Higuchi model.CONCLUSION It is a practically acceptable formulation by ether injection method.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

OBJECTIVE To study the formulation of CA4 liposome and evaluate its quality.METHODS Liposome was prepared with ether injection method by using the orthogonal design to screen the formulation.Its shape and particle sizes were determined by electronic microscopy and Zetamaster.The encapsulation efficiencies were determined by HPLC.The release behavior of the liposome were evaluated.RESULTS The average size was about 16.04 nm.The optimal preparation conditions of CA4 liposome were as follows: soybean phosphatidylcholine: cholesterol was 6∶1.The dosage of P,A,B were 2% ,2% and 20%.The average encapsulation efficiency of the liposome was 92.78%.Its in vitro release profile accorded with Higuchi model.CONCLUSION It is a practically acceptable formulation by ether injection method.

Key concepts: Liposome, Chemistry, Particle size, Phosphatidylcholine, Chromatography, Ether, Phospholipid, Organic chemistry

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Preparation and evaluation of CA4 liposome — Research Paper | ScholarLens