Expression and correlation of PTEN and survivin in ovarian epithelial carcinoma

Objective To investigate the expression and correlation of PTEN and survivin in ovarian epithelia carcinoma.Methods The expression of PTEN and survivin in 46 cases of benign epithelial ovarian tumor,40 cases of normal ovarian tissue,76 cases of epithelial ovarian cancer were determined by SP immunohistochemical method.Results The positive rate of PTEN in the ovarian carcer tissue was lower than that in the normal and benign ovarian tumors(P0.05).Survivin expression trend was opposite to that of PTEN.In ovarian epithelia carcinoma,negative correlation between expression of PTEN and survivin was observed(r=-0.527,P=0.001).No different expression of PTEN and survivin among histological types or ages was found(P0.05).The expression level of PTEN and surviving were associated with differentiation,clinic stage(P0.05).Conclusion PTEN and survivin may play an important role in the initiation,development of ovarian epithelia carcinoma and the combination of PTEN and survivin expression may be helpful in predicting the malignant degree and prognosis of ovarian epithelia cancer.