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Expression of PTEN and Survivin in basal cell carcinoma

QU Cai-ji

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Abstract

Objective: To explore the expression of PTEN and an anti-apoptosis factor Survivin and its significance in basal cell carcinoma (BCC). Methods: The expression and distribution of PTEN and Survivin in the skin lesion and normal skin were detected by immunohistochemical technique streptavidin - peroxidase (sp) in 20 cases of BCC and 30 normal controls. Results: The expression of PTEN was down - regulated in BCC ( P 0.05) . The expression of Survivin was up - regulated ( P 0.001). The expression of PTEN was not correlated with that of Survivin. Conclusion: The abnormal expression of PTEN and Survivin may contribute to the oncogenesis and development of BCC.

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What this paper is about

Objective: To explore the expression of PTEN and an anti-apoptosis factor Survivin and its significance in basal cell carcinoma (BCC). Methods: The expression and distribution of PTEN and Survivin in the skin lesion and normal skin were detected by immunohistochemical technique streptavidin - peroxidase (sp) in 20 cases of BCC and 30 normal controls. Results: The expression of PTEN was down - regulated in BCC ( P 0.05) . The expression of Survivin was up - regulated ( P 0.001). The expression of PTEN was not correlated with that of Survivin. Conclusion: The abnormal expression of PTEN and Survivin may contribute to the oncogenesis and development of BCC.

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Available abstract

Objective: To explore the expression of PTEN and an anti-apoptosis factor Survivin and its significance in basal cell carcinoma (BCC). Methods: The expression and distribution of PTEN and Survivin in the skin lesion and normal skin were detected by immunohistochemical technique streptavidin - peroxidase (sp) in 20 cases of BCC and 30 normal controls. Results: The expression of PTEN was down - regulated in BCC ( P 0.05) . The expression of Survivin was up - regulated ( P 0.001). The expression of PTEN was not correlated with that of Survivin. Conclusion: The abnormal expression of PTEN and Survivin may contribute to the oncogenesis and development of BCC.

Key concepts: Survivin, PTEN, Immunohistochemistry, Basal cell carcinoma, Carcinogenesis, Cancer research, Basal (medicine), Biology

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