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Expression of PTEN and Survivin in human squamous cell carcinoma

QU Cai-ji

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Abstract

Objective: To measure the expression of carcinoma-inhibiting protein PTEN and apoptosis inhibition factor Survivin and its significance in human squamous cell carcinoma. Methods: The expression and distribution of PTEN and Survivin in the skin lesion and normal skin were detected by immunohistochemical technique streptavidin-peroxidase (SP) in 40 cases of squamous cell carcinoma and 30 normal controls. Results: The expression of PTEN was down-regulated in squamous cell carcinoma (P0.001). The poorer the differentiation, the lower the level of the expression was (P0.001). However, the expression of Survivin was up-regulated (P0.001). The expression of PTEN was negatively correlated with the expression of Survivin (r=-0.896, P0.001). ~Conclusion : The abnormal expression of PTEN and Survivin may contribute to the oncogenesis of squamous cell carcinoma, and the level of PTEN may be a prognostic marker for squamous cell carcinoma.

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Objective: To measure the expression of carcinoma-inhibiting protein PTEN and apoptosis inhibition factor Survivin and its significance in human squamous cell carcinoma. Methods: The expression and distribution of PTEN and Survivin in the skin lesion and normal skin were detected by immunohistochemical technique streptavidin-peroxidase (SP) in 40 cases of squamous cell carcinoma and 30 normal controls. Results: The expression of PTEN was down-regulated in squamous cell carcinoma (P0.001). The poorer the differentiation, the lower the level of the expression was (P0.001). However, the expression of Survivin was up-regulated (P0.001). The expression of PTEN was negatively correlated with the expression of Survivin (r=-0.896, P0.001). ~Conclusion : The abnormal expression of PTEN and Survivin may contribute to the oncogenesis of squamous cell carcinoma, and the level of PTEN may be a prognostic marker for squamous cell carcinoma.

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Available abstract

Objective: To measure the expression of carcinoma-inhibiting protein PTEN and apoptosis inhibition factor Survivin and its significance in human squamous cell carcinoma. Methods: The expression and distribution of PTEN and Survivin in the skin lesion and normal skin were detected by immunohistochemical technique streptavidin-peroxidase (SP) in 40 cases of squamous cell carcinoma and 30 normal controls. Results: The expression of PTEN was down-regulated in squamous cell carcinoma (P0.001). The poorer the differentiation, the lower the level of the expression was (P0.001). However, the expression of Survivin was up-regulated (P0.001). The expression of PTEN was negatively correlated with the expression of Survivin (r=-0.896, P0.001). ~Conclusion : The abnormal expression of PTEN and Survivin may contribute to the oncogenesis of squamous cell carcinoma, and the level of PTEN may be a prognostic marker for squamous cell carcinoma.

Key concepts: PTEN, Survivin, Immunohistochemistry, Cancer research, Carcinogenesis, Carcinoma, Cell, Biology

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