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Expression and clinical significance of HMGB1 in ovarian carcinoma

Chen Chou-yan

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Abstract

Objective:To explore the expression and clinical significance of HMGB1 in ovarian carcinoma.Methods:ELISA method was used to detect the expression of serum HMGB1 in 26 ovarian carcinoma,40 benign ovarian tumor and 30 healthy women.Moreover,Immunohistochemical SABC method was used to detect the expression of HMGB1 in 26 ovarian carcinoma tissues and 40 benign ovarian tumor tissues.Results:The expression of HMGB1 were higher in ovarian carcinoma than that in the others,showing a significant difference(P0.05).There were no significant diference between normal control group and benign ovarian tumor group(P0.05).Conclusion:The expression of HMGB1 might be as one of the parameters for identifying benign ovarian tumor and ovarian carcinoma.

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What this paper is about

Objective:To explore the expression and clinical significance of HMGB1 in ovarian carcinoma.Methods:ELISA method was used to detect the expression of serum HMGB1 in 26 ovarian carcinoma,40 benign ovarian tumor and 30 healthy women.Moreover,Immunohistochemical SABC method was used to detect the expression of HMGB1 in 26 ovarian carcinoma tissues and 40 benign ovarian tumor tissues.Results:The expression of HMGB1 were higher in ovarian carcinoma than that in the others,showing a significant difference(P0.05).There were no significant diference between normal control group and benign ovarian tumor group(P0.05).Conclusion:The expression of HMGB1 might be as one of the parameters for identifying benign ovarian tumor and ovarian carcinoma.

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Available abstract

Objective:To explore the expression and clinical significance of HMGB1 in ovarian carcinoma.Methods:ELISA method was used to detect the expression of serum HMGB1 in 26 ovarian carcinoma,40 benign ovarian tumor and 30 healthy women.Moreover,Immunohistochemical SABC method was used to detect the expression of HMGB1 in 26 ovarian carcinoma tissues and 40 benign ovarian tumor tissues.Results:The expression of HMGB1 were higher in ovarian carcinoma than that in the others,showing a significant difference(P0.05).There were no significant diference between normal control group and benign ovarian tumor group(P0.05).Conclusion:The expression of HMGB1 might be as one of the parameters for identifying benign ovarian tumor and ovarian carcinoma.

Key concepts: Ovarian carcinoma, Immunohistochemistry, Ovarian tumor, HMGB1, Medicine, Ovarian cancer, Pathology, Ovarian tissue

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