2012•Chongqing Yike Daxue xuebaoRequires access

Expression and significance of HMGB1 and E-cadherin in ovarian carcinoma

Rui Yuan

Abstract

Objective:To explore the expression and clinical significance of high mobility group box-1(HMGB1) and E-cadherin in ovarian carcinoma.Methods:Between May 2008 and January 2011,immunohistochemical SP method was used to detect the expression of HMGB1 and E-cadherin in 75 patients with ovarian carcinoma and 40 normal ovarian tissues and to analyze the clinical pathological significance of HMGB1 and E-cadherin in ovarian carcinoma.Results:The positive expression of E-cadherin was lower in ovarian carcinoma than in normal ovarian tissues(χ2=12.62,P0.01).The positive expression of HMGB1 was higher in ovarian carcinoma than in normal ovarian tissues(58/75 vs.4/40,χ2=47.60,P0.01).The expression pattern of HMGB1 and E-cadherin were associated with clinical stage and lymph node metastasis(P0.05),but not with histological subtypes and histological stages(P 0.05).The expression of HMGB1 was negatively correlated with E-cadherin(r=-0.299,P0.01) in ovarian cancer.Conclusion:HMGB1 and E-cadherin might play an important role in the carcinogenesis and metastasis of ovarian carcinoma.

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Key concepts: Ovarian carcinoma, Cadherin, Immunohistochemistry, Ovarian cancer, Lymph node metastasis, Pathological, Stage (stratigraphy), Carcinoma