Effect of Xuanfu Daizhe Decoction on nitric oxide concentration of esophageal mucosa in reflux esophagitis rat model

Objective It is to observe the effect of Xuanfu Daizhe Decoction (XDD) on reflux esophagitis and to discuss the action mechanism.Methods The rat models were made with ligating the pylori partly and lower esophagus sphincterotomy (LES). They were randomly divided into five groups and treated with different methods. Then their nitric oxide concentrations of esophageal mucosa were observed.Results ①The body mass increased values in traditional Chinese medicine (TCM) group and western medicine (WM) group were significantly different with that in placebo group (P0.001).②The naked eye observing scores in TCM group and WM group were significantly different with that in placebo group (P0.001).③The pathomorphology light microscope scores in TCM group and WM group were significantly different with that in placebo group (P0.001).④The nitric oxide concentrations of esophageal mucosa in TCM group and WM group were significantly different with that in placebo group (P0.05).Conclusion XDD can improve the esophageal mucosa pathology condition of rat models. The action mechanism maybe is that the nitric oxide concentration of esophageal mucosa of rat model is reduced, the inflammation reaction is lightened and the lower esophageal sphincter relaxation is reduced.