Effects of Zuogui Jiangtang Yishen Decoction on blood glucose,blood lipids,renal function and the serum content of IL-6,TNF-α of MKR mice with diabetic nephropathy

Objective: To observe the ef ects of ZuogufiJiangtang Yishen Decoction(ZJYD) on blood glucose, blood lipids, renal function, serum inflammatory factors of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in MKR mice with diabetic nephropathy. Method: 8 weeks of MKR mice, which were dominant-negative insulin-like growth factor-1 receptor specifically targeted to the skeletal muscle were randomly divided into 5 groups: control group, high fat diet feed group, high-fat diet feed and mono-nephrectomy model group, ZJYD group, and positive control group(PCG), according to sex, fasting bloodglucose and body weight; 15 mice in each group. Fifteen C57 mice was as normal group. Four weeks after operation, the mice were gavaged for 30 days of ZJYD of 14.4g/kg; observing the fasting blood-glucose and blood lipids, renal function, serum contents of TNF-α and IL-6. Results: Compared to model group, ZJYD can low the fasting blood-glucose and blood lipids, improve the renal function, low the serum contents of TNF-α and IL-6, with significant differences(P 0.05, P 0.01). Compared with the positive control, the ef ect of lowing the content of IL-6 was superior to PCG; and the ef ect of improving the renal function, lowing serum content of TNF-α and blood lipids was as good as PCG; but the ef ect of lowing blood glucose was inferiorto PCG. Conclusion: The ZJYD of 14.4g/kg have good results of improving the renal function, lowing serum content of TNF-α and IL-6 and blood lipids of diabetic nephropathy in MKR mice.