Renal Protective Effects of Qidan Yishen Jiangtang Capsule on Diabetic Nephropathy in Rats

Objective:To study the renal protective effects of Qidan Yishen Jiangtang Capsule(QYJC)in diabetic nephropathy rats.Method:The DN rats model was established by one side nephrectomy and intraperitoneal injection of streptozotocin.Then rats were randomly divided into 3 groups: sham-operation group,model group,QYJC group,10 in each group.Rats were given the relevant drugs respectively for 12 weeks.Finally the levels of body weight(BW),fasting blood glucose(FBG),blood urea nitrogen(BUN),serum creatine(SCr),albumin(ALB),total cholesterol(TC),triglyceride(TG),24-hour urinary protein excretion(UPE)were detected.The kidney tissue was taken for histopathological observation and lesion grade.Result:QYJC decreased the levels of FBG,BUN,TC,TG,UAE significantly(P 0.05 or 0.01),it also reduced glomerulosclerosis index(P 0.05 or 0.01) and tubu-lointerstitial fibrosis index(P 0.05 or 0.01)as compared with DN model group.Conclusion: QYJC has a good re-nal protective effect in rats with diabetic nephropathy.The mechanism may be related to relieving blood lipid metabo-lism disorders.