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2010•Military Medical Journal of South ChinaRequires access

Diagnostic Value of Urinary Low Molecular Weight Protein Marker in Patients with Early Diabetic Nephropathy

Xuan Zhang

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Abstract

Objective To investigate the diagnostic value of combined detection of urinary α1-microglobulin (α1-MG),β2 -microglobulin (β2-MG) and microalbumin (MAlb) in patients with early diabetic nephropathy (DN).Methods Methodnephelometry,microparticle immunoluminescence technique and immune transmission were utilized to detect the level of urinary α1-MG,β2-MG and MAlb in 45 patients with diabetes and 50 health persons.Results MAlb,α1-MG and β2-MG were significantly higher in patients than in healthy controls (P0.05).As for the positive rates,α1-MGβ2-MGMAlb.The pairwise correlation among α1-MG,β2-MG and MA1b were all positive in the diabetic group.Conclusion Combined detection of urinaryα1-MG,β2-MG and MAlb was significant for early detection,early diagnosis and treatment for DN patients.

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What this paper is about

Objective To investigate the diagnostic value of combined detection of urinary α1-microglobulin (α1-MG),β2 -microglobulin (β2-MG) and microalbumin (MAlb) in patients with early diabetic nephropathy (DN).Methods Methodnephelometry,microparticle immunoluminescence technique and immune transmission were utilized to detect the level of urinary α1-MG,β2-MG and MAlb in 45 patients with diabetes and 50 health persons.Results MAlb,α1-MG and β2-MG were significantly higher in patients than in healthy controls (P0.05).As for the positive rates,α1-MGβ2-MGMAlb.The pairwise correlation among α1-MG,β2-MG and MA1b were all positive in the diabetic group.Conclusion Combined detection of urinaryα1-MG,β2-MG and MAlb was significant for early detection,early diagnosis and treatment for DN patients.

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Available abstract

Objective To investigate the diagnostic value of combined detection of urinary α1-microglobulin (α1-MG),β2 -microglobulin (β2-MG) and microalbumin (MAlb) in patients with early diabetic nephropathy (DN).Methods Methodnephelometry,microparticle immunoluminescence technique and immune transmission were utilized to detect the level of urinary α1-MG,β2-MG and MAlb in 45 patients with diabetes and 50 health persons.Results MAlb,α1-MG and β2-MG were significantly higher in patients than in healthy controls (P0.05).As for the positive rates,α1-MGβ2-MGMAlb.The pairwise correlation among α1-MG,β2-MG and MA1b were all positive in the diabetic group.Conclusion Combined detection of urinaryα1-MG,β2-MG and MAlb was significant for early detection,early diagnosis and treatment for DN patients.

Key concepts: Urinary system, Medicine, Beta-2 microglobulin, Diabetic nephropathy, Diabetes mellitus, Gastroenterology, Urology, Internal medicine

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