Antibiotic resistance of Neisseria gonorrhoeae in Guangzhou: an analysis result

Objective To investigate the antibiotic resistance and the prevalence of PPNG and TRNG in Guangzhou.Method Minimum inhibitory concentrations(MICs) to ceftriaxone,spectiomycin,ciprofloxacin,azithromyc and tetracycline were determined using the agar dilution method,and β-lactamase by paper iodine quantitative method.Result 24 strains of Neisseria gonorrhoeae producing β-lactamase were detected in 83 strains,while 50 strains showed plasmid-mediated,high-level resistance to tetracycline(TRNG).Resistance rate to ciprofloxacin was 98.8%.43 strains were highly resistant(MIC≥16 mg/L)(51.8%).Resistance rate to azithromyc was 14.5%(11/76).No strains were found to be resistant to ceftriaxone and specitinomycin.Conclusion Using antibiotics rationally and the changes of resistance being monitored dynamically can effectively reduce the occurance of more resistant strains of Neisseriae gonorrhoeae.