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Analysis of antibiotic resistance of Neisseria gonorrhoeae in Guangzhou.

Wenling Cao, Xiaodong Li, Chao Bi, Xin Tian, Liang Yan-hua, Song Wei-zhong, Luyang Lin, Zhang Xibao

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Abstract

Objective To explore the antibiotic resistance and the prevalence of PPNG and TRNG in Guangzhou.Method Minimum inhibitory concentrations(MIC) to penicillin G,tetracycline,ciprofloxacin,ceftriaxone and spectiomycin were determined using the agar dilution method,and β-lactamase by paper iodin quantitative method.Result Of the total 74 strains of Neisseria gonorrhoeae produced β-lactamase,while 19 strains showed plasmid-mediated,high-level resistance to tetracycline(TRNG).The resistant rates to ciprofloxacin was as much as 97.3%;22 strains were highly resistant(MIC=16 mg/L).No strains were found to be resistant to ceftriaxone and specitinomycin.Conclusion The study showed that it is important to successively monitor the antibiotic resistance.of Neisseriae gonorrhoeae.

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Objective To explore the antibiotic resistance and the prevalence of PPNG and TRNG in Guangzhou.Method Minimum inhibitory concentrations(MIC) to penicillin G,tetracycline,ciprofloxacin,ceftriaxone and spectiomycin were determined using the agar dilution method,and β-lactamase by paper iodin quantitative method.Result Of the total 74 strains of Neisseria gonorrhoeae produced β-lactamase,while 19 strains showed plasmid-mediated,high-level resistance to tetracycline(TRNG).The resistant rates to ciprofloxacin was as much as 97.3%;22 strains were highly resistant(MIC=16 mg/L).No strains were found to be resistant to ceftriaxone and specitinomycin.Conclusion The study showed that it is important to successively monitor the antibiotic resistance.of Neisseriae gonorrhoeae.

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Available abstract

Objective To explore the antibiotic resistance and the prevalence of PPNG and TRNG in Guangzhou.Method Minimum inhibitory concentrations(MIC) to penicillin G,tetracycline,ciprofloxacin,ceftriaxone and spectiomycin were determined using the agar dilution method,and β-lactamase by paper iodin quantitative method.Result Of the total 74 strains of Neisseria gonorrhoeae produced β-lactamase,while 19 strains showed plasmid-mediated,high-level resistance to tetracycline(TRNG).The resistant rates to ciprofloxacin was as much as 97.3%;22 strains were highly resistant(MIC=16 mg/L).No strains were found to be resistant to ceftriaxone and specitinomycin.Conclusion The study showed that it is important to successively monitor the antibiotic resistance.of Neisseriae gonorrhoeae.

Key concepts: Neisseria gonorrhoeae, Microbiology, Tetracycline, Ciprofloxacin, Penicillin, Ceftriaxone, Antibiotics, Antibiotic resistance

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Analysis of antibiotic resistance of Neisseria gonorrhoeae in Guangzhou. — Research Paper | ScholarLens