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2010•Xinxueguan kangfu yixue zazhiRequires access

Clinical effect of Bisoprolol in treatment of chronic heart failure

Liao Hong

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Abstract

Objective:To observe the effect of Bisoprolol for the patients with chronic heart failure.Methods:A total of 104 patients with chronic heart failure were divided into two groups.The control group(n=52) was treated by routine medicines (digitalis、diuretic、 blood-vessel dilator) combined Imidapril.The treatment group(n=52) was treated by routine medicines combined Imidapril and Bisoprolol.The course of treatment was 12-16 weeks.The changes of the LVEF、LVEDd、 LVESd、 heart rate (HR)and blood pressure were observed before and after treatment.Results:The total effective rate of treatment group was higher than that of control group(92.31% vs.73.08%,P0.05).The levels of LVSDd significantly decreased in treatment group [(49.86±5.20)mm vs.(61.80±4.58)mm,P0.05]and more than that of control group [(49.86±5.20)mm vs.(57.65±4.20)mm,P0.05]after treatment.The levels of LVEF improved(P0.05～0.01)in both two groups before and after treatment,compared with control group,that of treatment group increased more than[(37.58±3.15)% vs.(48.84±4.45)%,P0.05].SBP、DBP and HR significantly improved(P0.05～0.01)in treatment group,DBP[(69.4±12.98)mmHg vs.(75.97±13.62)mmHg] and HR[(70.99±10.7)vs.(75.73±9.4)] were more decreased than those of control group (P0.05 all).Conclusion:It is more effect that the routine medicines and Imidapril combined Bisoprolol for the patients with chronic heart failure.

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What this paper is about

Objective:To observe the effect of Bisoprolol for the patients with chronic heart failure.Methods:A total of 104 patients with chronic heart failure were divided into two groups.The control group(n=52) was treated by routine medicines (digitalis、diuretic、 blood-vessel dilator) combined Imidapril.The treatment group(n=52) was treated by routine medicines combined Imidapril and Bisoprolol.The course of treatment was 12-16 weeks.The changes of the LVEF、LVEDd、 LVESd、 heart rate (HR)and blood pressure were observed before and after treatment.Results:The total effective rate of treatment group was higher than that of control group(92.31% vs.73.08%,P0.05).The levels of LVSDd significantly decreased in treatment group [(49.86±5.20)mm vs.(61.80±4.58)mm,P0.05]and more than that of control group [(49.86±5.20)mm vs.(57.65±4.20)mm,P0.05]after treatment.The levels of LVEF improved(P0.05～0.01)in both two groups before and after treatment,compared with control group,that of treatment group increased more than[(37.58±3.15)% vs.(48.84±4.45)%,P0.05].SBP、DBP and HR significantly improved(P0.05～0.01)in treatment group,DBP[(69.4±12.98)mmHg vs.(75.97±13.62)mmHg] and HR[(70.99±10.7)vs.(75.73±9.4)] were more decreased than those of control group (P0.05 all).Conclusion:It is more effect that the routine medicines and Imidapril combined Bisoprolol for the patients with chronic heart failure.

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Available abstract

Objective:To observe the effect of Bisoprolol for the patients with chronic heart failure.Methods:A total of 104 patients with chronic heart failure were divided into two groups.The control group(n=52) was treated by routine medicines (digitalis、diuretic、 blood-vessel dilator) combined Imidapril.The treatment group(n=52) was treated by routine medicines combined Imidapril and Bisoprolol.The course of treatment was 12-16 weeks.The changes of the LVEF、LVEDd、 LVESd、 heart rate (HR)and blood pressure were observed before and after treatment.Results:The total effective rate of treatment group was higher than that of control group(92.31% vs.73.08%,P0.05).The levels of LVSDd significantly decreased in treatment group [(49.86±5.20)mm vs.(61.80±4.58)mm,P0.05]and more than that of control group [(49.86±5.20)mm vs.(57.65±4.20)mm,P0.05]after treatment.The levels of LVEF improved(P0.05～0.01)in both two groups before and after treatment,compared with control group,that of treatment group increased more than[(37.58±3.15)% vs.(48.84±4.45)%,P0.05].SBP、DBP and HR significantly improved(P0.05～0.01)in treatment group,DBP[(69.4±12.98)mmHg vs.(75.97±13.62)mmHg] and HR[(70.99±10.7)vs.(75.73±9.4)] were more decreased than those of control group (P0.05 all).Conclusion:It is more effect that the routine medicines and Imidapril combined Bisoprolol for the patients with chronic heart failure.

Key concepts: Medicine, Bisoprolol, Ejection fraction, Heart failure, Internal medicine, Diuretic, Dilator, Treatment and control groups

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