Bisoprolol in treatment of congestive heart failure of caronary heart disease

Objective:To observe the effect of bisoprolol(β receptor paralyzer) in the treatment of congestive heart failure of caronary heart disease.Methods:Thirty seven patients who were graded as Ⅲ to Ⅳ caronary heart disease according the criteria by NYHA were treated with digitalis,diuretic and angiotensin converting enzyme inhibitor.After getting into a relatively stable condition,they were divided into two groups:treatment group(17 cases) and control group(20 cases,routine treatment).The treatment group received,besides routine treatment,bisoprolol(1.25 mg/d) which was increased 1.25 mg every two weeks.The max dosage was 5 mg/d.The treatment course lasted for 12 weeks.Results:The LVEDD and LVESD of the two groups before treatment significantly were reduced( P 0.01),EF was increased obviously( P 0.01),and heart rate was reduced greatly( P 0.01);After treatment,the LVEDD\,LVESD,EF,heart rate and ventricular number in the group with bisoprolol more improved significantly( P 0.01, P 0.01, P 0.01, P 0.01, P 0.05,respectively).Conclusions:Bisoprolol(β receptor paralyzer) can reduce the ventricular volume which had been recombinatively repaired and the incidence rate of ventricular arrhythmias.It can also improve EF and slow down heart rate.