Observation on the effect of bisoprolol on chronic heart failure

Objective To observe the clinical effect of bisoprolol, a highly selective β1-receptor blocker, on chronic heart failure (CHF). Methods 80 patients with CHF were divided randomly into regular treatment group treated with diuretic+digoxin+ACEI, and bisoprolol treatment group treated with regular treatment plus bisoprolol. All the patients were followed up for twelve months and observed the changes of homodynamic, internal diameter of left ventricle, LVEF and 6-minutes walk test. Results Twelve months after treatment the levels of HR, XSBP and HR’SBP in paitents of the two groups dropped significantly compared with pre-treatment, particularly in bisoprolol group, the levels of HR and SBP were (78±5.7)/min and (131.27±12.66)mmHg, higher than those in regular treatment group[(92±6.2)/min,(146.13±12.79)mmHg (P0.01)]. After treatment, the levels of HR,SBP and HRSBP in patients of the two groups during six-minutes walk test were all decreased, the walking distance increased obviously compared with pre-treatment, particularly in bisoprolol group . The levels of HR and SBP were (85.94±5.38)/min and (116.77±11.51)mmHg, showing significant differences as compared with that of regular treatment group (103.70±6.9)/min,(120.75±9.90)mmHg, (P0.01). Conclusion Bisoprolol is effective for treatment of chronic heart failure as it can delay ventricular remodeling, prevent cardiac dilating and improve cardiac function further on the basis of ACEI in addition to enhancement of cardiac reserve and prevention of exercise fatigue in CHF patients.