The relationship between polymorphism of interleukin-1α C-889T and patients with coronary heart disease

Objective:To observe the frequencies of the polymorphism of IL-1αC-889T in Chinese and the relationship between the polymorphism of IL-1αC-889T and coronary artery disease(CHD). Method:IL-1αC-889T polymorphism was performed in 282 patients who were performed selective coronary angography by using PCR-RFLP methods. The patients were classfied as 126 CHD patients group and 156 controls group. The relationship between the polymorphism of IL-1αC-889T and the plasma levels of CRP were also investigated. Result:The frequencies of genotype in Chinese was CC ~78.7 %,CT ~20.6 %, TT ~0.7 %. The frequencies of allele was C 502 (~89.0 %),T 62 (~11.0 %).The genotype distribution was in accordance with Hardy- Weinberg equilibrilum. A significant increase was found for the IL-1a T allele in CHD patients compared with controls(~28.6 % vs~15.4 % , χ2=~7.24 ,P~0.01 ). There was no relationship between the polymorphism of IL-1αC-889T and myocardial infarction、the number of stenotic vessels. There was no relationship between the polymorphism and the plasma levels of CRP. Hypertension, hypercholesterolemia and type 2 diabetes were not the confounding factors. Conclusion: The polymorphism of IL-1αC-889T is present in Chinese and the T allele is a major risk factor for CHD patients.