Correlation between the polymorphism in the promoter region of interleukin-1α gene with the coronary heart disease

Objective To analyze the correlation between the C/T polymorphism at position -889 in the promoter region of interleukin-1α (IL-1α) gene and the coronary heart disease (CHD) in Shanghai. Methods MALDI-TOF MassARRAY system was used to genotyping the C-889T polymorphism in 94 normotensive patients with CHD and 100 healthy controls. Results The genotype distribution of the C-889T polymorphism was significantly different between the CHD group (CC=83, CT=11) and the controls (CC=76, CT=24; P=0.026). The frequencies of C and T alleles were also obviously different between the two groups(94.15% and 5.85% vs 88.00% and 22.00%;P=0.035). The genotype distribution and alleles frequencies of the C-889T polymorphism were obviously different between the patients with double-vessel disease (DVD) and triple-vessel disease (TVD) and controls (46 and 5 vs 76 and 24, P=0.036; 95.10% and 4.90% vs 88.00% and 22.00%, P=0.048). Conclusions The C-889T polymorphism in the promoter region of IL-1α gene might be a genetic risk factor for CHD in normotensive patients, which might be also associated with the extent of coronary atherosclerosis.