The relationships between the TaqI polymorphism of interleukin-1 β and the risk of coronary heart diseases,the concentration of C-reactive protein

Objective To investigate the relationships between the TaqⅠpolymorphism of interleukin- 1β (IL-1β) gene with the risk of coronary heart diseases(CHD) and the concentration of C-reactive protein (CRP). Methods The genotype and allele frequencies of Taq1 polymorphism of IL-1β gene were identified by polymerase chain reaction(PCR)- restriction fragment length polymorphism (RFLP) in 78 CHD patients and 130 healthy people, and the differences of concentrations of CRP in different genotype was analysis. Results The C allele frequency of IL-1β gene in controls and CHD patients were 0.942, 0.965 respectively,and T allele frequency were 0.058, 0.035 respectively. There were no significant differences in frequencies of genotype and allele between controls and CHD patients ( P 0.05), but the concentrations of CRP in different genotype and allele subgroups of controls have significant differences ( P 0.05). Conclusions These results suggest polymorphism of IL-1β was associated with the concentrations of CRP in normal people but not with CHD.