The relationship between interleukin-6/-572C/G polymorphism and coronary heart disease and polymorphism's effect on serum interleukin-6 level

Objective:To explore the relationship between interleukin-6(IL-6) gene -572C/G polymorphism and coronary heart disease(CHD) and polymorphism's effects on serum IL-6 level.Method:IL-6/-572C/G polymorphism was genotyped in 245 CHD patients and 260 healthy donors by PCR-RFLP method. Serum IL-6 level was examined by ELISA method.Result:IL-6/-572GG genotype and G allele were more frequent in CHD patients than in healthy donors (P0.01) .Compared with CC genotype, the relative for CHD patients was 1.46(95% CI: 1.01~2.10,P0.05) for CG genotype and 5.19(95% CI:1.69~15.89,P0.01) for GG genotype. The serum levels of IL-6 were not different between carriers of the IL-6/-572G allele and patients with CC genotype(P0.05).Conclusion:IL-6/-572C/G polymorphism may be a possible genetic susceptibility factor for CHD in Chinese Hans population, but it does not affect serum IL-6 level.