2005•Journal of Internal Intensive MedicineRequires access
The relationship between expression of nm23-H1 and lymphnods metastasis
Cai Gangxian
Open publisher page 0 citations
Abstract
Objective:To investigate the relationship between expression of nm23-H1 gene and lymph node metastasis. Methods: FCM was used to detect protein expression of nm23-H1 gene and cell cycle distribution. Results:All normal gastric tissue cells were diploid,18 of 28 gastric cancer showed heteroloid, Lymph node metastasis were detected in 14 of 18( 77.78%) heteroloid tumors and in 3 of 10 (30%) nonheteroloid tumor. PI(proliferation index) was 2.04% in normal gastric tissues. And PI of gastric carcinoma was 12.69%± 6.78%. PI of gastric carcinoma with lymph node metastasis was 14.86%± 8.41% higher than gastric carcinoma without lymph node metastasis ( 10.51%± 4.89%). (P 0.05) Expression of nm23-H1 was negative in normal gastric tissues. FI of nm23-H1 was 0.73± 0.36. FI(fluent index) of gastric carcinoma with lymph node metastasis was 0.42± 0.24, lower than gastric carcinoma without lymph node metastasis ( 1.04± 0.17). (P 0.05).FI of nm23-H1 gene was 1.01± 0.21 in nonheteroloid gastric carcinoma higher than heteroloid gastric carcinoma ( 0.45± 0.29)(P 0.05). Conclusion:Lymph node metastasis of gastric carcinoma is related to heteroloid、high proliferation and expression nm23-H1.