2006•Journal of Jilin UniversityRequires access
Expression of cyclooxygenase-2 in gastric carcinoma and its relationship with patho-parameters
Yang Wang
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Abstract
Objective To investigate the expression of of cyclooxygenase-2(COX-2) in human gastric carcinoma and to identify the significance of COX2 expression. Methods COX-2 protein expressions were deteced in 12 nomal gastric mucosa and 40 gastric carcinoma tissues by immunohistochemistry.Results The expression of COX-2 in gastric carcinoma tissues(87.5%) was significantly higher than that in normal gastric mucosa(25.0%)(P0.05).The expression of COX-2 in Ⅲ+Ⅳ stage of gastric carcinoma(96.55%) was higher than that in Ⅰ+Ⅱ stage(63.64%)(P0.05);the COX-2 expression in lymph node metastasis group(96.43%) was higher than that in non-lymph node metastasis group(66.67%)(P0.05).Conclusion The expression of COX-2 is related to TNM stages and lymph node metastasis.The expression of COX-2 maybe take part in the progress of gastric carcinoma and related to invasion,metastasis and prognosis.