Study on nm23-H_1 Expression in Gastric Carcinoma

Objective To study nm23?H 1 expression in gastric carcinoma and its relation with tumor differentiation, invasion and metastasis.Methods nm23?H 1 expression was detected by using ABC immunohistochemical method.Results 45.6% of the primary tumors ( n =21) showed negative nm23?H 1 expression. No significant correlation was found between positive nm23?H 1 expression and Borrmann classification., histologic classification ( P 0.05). Significant correlation was observed between nm23?H 1 expression and tumor diameter, depth of invasion, clinicopathologic stage, lymph node metastasis ( P 0.05). 54.0% of gastric carcinomas expressed positive nm23?H 1 at the site of primary tumors. Only 37.5% of the lymph node metastasis showed positive nm23?H 1.Conclusion Decrease of nm23?H 1 expression correlates with depth of invasion and lymph node metastasis, and there is no relationship between nm23?H 1 expression and differentiation of gastric carcinoma.