Clinical Significance of the Changes of Serum Muscle Enzyme Spectrum in Patients with Cerebral Hemorrhage

Objective:To analyze the changes of the serum muscle enzyme spectrum and its clinical significance in patients with cerebral hemorrhage.Methods: One hundred and eighty six patients with acute cerebral hemorrhage(cerebral hemorrhage group) and eighty six patients with functional headache(control group) were enrolled.The serum muscle enzyme(CK,CK-MB,LDH,AST) levels of patients in the two groups were measured and compared.The differences of muscle enzyme spectrum changes among cerebral hemorrhage patients with different position of bleeding,amount of bleeding,conscious state,prognosis and state of blood whether or not broken into the ventricle were compared and analyzed.Results: The serum CK,LDH and AST levels of patients in the cerebral hemorrhage group were obviously higher than those in the control group(P0.05).There was no significant difference in muscle enzyme spectrum level of cerebral hemorrhage pat ients with different position of bleeding.Only LDH level of cerebral hemorrhage patients with blood broken into the ventricle was significantly higher than that of patients without blood broken into the ventricle(P0.05).The serum muscle enzyme of patients with severe disturbance of consciousness was higher than that of patients with mild disturbance of consc iousne ss(P0.05).The CK and LDH level of patients with large amount of bleeding were significantly higher than those of patients with small amount of bleeding(P0.05).Only LDH level of the death was significantly higher than that of the survivors(P0.05).Conclusion: The elevation of serum muscle enzymes(especially CK and LDH)in acute phase of cerebral hemorrhage is helpful in assessing the severity of the disease,while LDH is valuable for the judgment of the recent prognosis of the disease.