Prenatal screening analysis for Down syndrome by using of three maternal serum markers on 6712 cases

Objective:To investigate the effect of prenatal screening for Down syndrome(DS) by serum AFP,unconjugateg estriol(uE3) and T-βHCG in pregnant women.Methods:Used a method based on detecting serum AFP/ uE3/T-βHCG concenttrrations in pregnant women for 14-21weeks,and combination with maternal age,children weeks,avoirdupois and so on,we evaluated the risk with risk evaluation sofeware.Then compared the results while type –B ultrasonic,amniocentesis,and result of newsborn′s examination.Results:Among the high risk cases of 6712,357 cases indicate DS and 82 cases suggest Trisomy 18,By amniocentesis,5 cases were diagnosed Down′s syndrome;2 cases were diagnosed Trisomy 18;78 examples with neural tube defect high risk were checked,12 cases of neural tube defect were diagnosed.Conclusion:By the prenatal screening of serums AFP/ T-βHCG /uE3,it decreased the rate of birth defects.And it is a very effective technic means to caary out our country,sprepotency policy.