Changes and clinical significance of platelet parameters in children with Kawasaki disease

Objective To explore the clinical significance of platelet parameter change in children with Kawasaki disease (KD). Methods The platelet count (PLT),mean platelet volume (MPV), plateletcrit (PCT), platelet distribution width (PDW) in 38 cases of KD were detected and compared with 38 normal children. Results The levels of blood PLT, PDW in KD children at acute stage was significantly higher than that of normal children (P0.001). The level of PCT in KD children at acute stage was higher than normal children (P0.05), MPV in KD children at acute stage was unchanged as compared with that of normal children (P0.05). The levels of PLT, PCT, PDW at early recovery stage were singnificantly higher than those of normal children (P0.001), MPV at early recovery stage was lower than those of normal children (P0.001); the levels of PLT, PCT at early recovery stage were significantly higher than those of KD children at acute stage (P0.01). The parameters of MPV and PDW at early recovery stage were lower than those of KD children at acute stage (P0.01). Conclusion Platelet parameter could be used in judging the recovery degree of KD children and guiding yuse of clinical therapeutic drug.