Clinical Significance of Platelet Parameters in Diagnosis of Kawasaki Disease

Objective To explore the clinical value of platelet parameters changes in the first week and the second to third week among the children with Kawasaki disease(KD).Methods The venous blood samples from 78 children with KD(case group) and 78 healthy children with medical examination(control group) were collected for the determination of the platelet count(PLT),plateletcrit(PCT),mean platelet volume(MPV),and platelet distribution width(PDW) by ADVIA2120 Automatic Blood Cell Analyzer.The determination results of the two groups were compared and analyzed.Results The blood levels of PLT and PCT in KD children at the first week were significantly higher than those of normal children(P0.05), while the level of PDW in KD children at the first week was lower than that of normal children(P0.05).No statistically significant difference was found in the level of MPV at the first week between KD children and normal children.The levels of PLT and PCT at the second to third week in KD children were significantly higher than those of normal children(P0.05),while the levels of MPV and PDW at the second to third week in KD children was lower than those of normal children(P0.05).Among the KD children,the levels of PLT and PCT at the second to third week were significantly higher than those at the first week,while the levels of MPV and PDW at the second to third week were lower than those at the first week.Among the KD children,the level of PLT was negatively correlated with those of MPV and PDW(r=-0.391,r=-0.362),but positively correlated with that of PCT(r=0.969).The level of PCT was negatively correlated with that of PDW(r=-0.356).No correlation was found between the level of MPV and the levels of PCT and PDW(r=-0.207,r=0.226).Conclusions The changes of platelet parameters play a very important role in the diagnosis of KD;moreover,they could be used in judging the condition of KD children and guiding clinical medication.