Study on anti-inflammatory mechanisms of resveratrol on cerebral ischemia reperfusion injury of rats

Objective:To investigate the anti-inflammatory mechanisms of resveratrol on cerebral ischemia reperfusion in-jury(CIRI) of rats.Methods:The model of MCAO was established by intraluminal suture technique.After 2 h of occlusion and 24 h of reperfusion,the rats of the high dose resveratral(40 mg/kg) group and low dose resveratrol(10 mg/kg) group were injected by intraperitoneal injection for 7 days,respectively,and the control group were given normal saline(2 ml/kg),one time a day,and all groups were given a more time in 15 minutes before operation.The contents of NO and activities of MPO in brain tissue of ischemic hemisphere were measured;the expression of ICAM-1 in the cortex were measured by immunohistochemical method.Results:The neurological scores of rats treated with resveratrol was reduced apparently compared with model group rats(P0.05);there were apparent reduction of the contents of NO and marked decrease of MPO in Resveratrol group compared with the I/R model group(P0.05);compared with I/R model group,the expression of ICAM-1 was down-regulated obviously in resveratral group(P0.05).Conclusion:Resveratrol could relieve the cerebral ischemia reperfu-sion injury,one of the mechanisms could be the anti-inflammatory effect of procyanidin