The relationship between the level of serum resistin and insulin resistance in the elderly patients with type 2 diabetes mellitus

Objective The purpose of this study was to investigate the potential roles of the resistin in the elderly patients with type 2 diabetes,and to evaluate the correlations among resistin and markers of obesity,insulin resistance,high sensitivity C reactive protein(hs-CRP),free fat acid(FFA) and metabolic parameters.Methods Eighty-two cases of elderly patients suffering from type 2 diabetes mellitus were randomly selected from June 2009 to February 2010.According to BMI which were divided into non obese type 2 DM group(40 cases) and obese type 2 DM group(42 cases).Another 30 healthy elderly people were enrolled as normal control group.The serum resistin and metabolic parameters were detected,and correlation study was performed.Results The concentrations of resistin in non-obese type 2 DM and obese type 2 DM groups were statistically higher than that of the normal control group(P0.05,P0.01 respectively).The level of serum resistin in obese type 2 DM group was statistically higher than that of non-obese type 2 DM group(P0.01 ).A significantly higher concentration of serum FFA was observed in obese type 2 DM group in comparison to non-obese type 2 DM and the control group (all P0.01).Multivariate stepwise regression analysis demonstrated that the level of resistin was influenced by the HOMAIR and WHR.Conclusion It is showed that the level of serum resistin was significance higher in elderly type 2 DM patients, especially in obesity cases.The HOMA-IR and WHR were the important factors to influence the level of resistin.In conclusion, the resistin may play an important role in insulin resistance,obesity and diabetes mellitus.