Correlation between serum resistin and insulin resistance in patients with obesity and newly-diagnosed type 2 diabetes mellitus

Objective To explore the relationship of fasting serum resistin with obesity and insulin resistance in patients with obesity and newly diagnosed type 2 diabetes.Methods The obese patients with T2DM (n = 48),non-obese patients with type 2 diabetes (n = 48) and healthy controls (n = 50) were enrolled.Fasting serum levels of resistin,glucose,lipids and insulin were measured.Their body height, body weight and blood pressure were measured and BMI and HOMA-IR were calculated.Results (1) Compared with control and patients with non-obese type 2 diabetes,the level of serum resistin in obese patients with type 2 diabetic was much higher (P0.01).(2)The level of serum resistin was correlated with HOMA-IR,BMI and triglyceride (P0.01).Conclusion The serum resistin level in patient with type 2 diabetic is elevated and correlated with obesity and insulin resistance.Resistin may play a pivotal role in the development of type 2 diabetes.