Pharmacokinetics of a Single dose of Omeprazole in Chinese Mongolian and Han Nationalities Healthy Volunteers

Aim To study the pharmacokinetics of omeprazole tablets after a single oral dose in Mongolian and Han healthy volunteers.Methods Twenty volunteers were involved in the study:ten Mongolian and ten Han volunteers. Each healthy volunlteer was given a single oral dose (40mg) of omeprazole tablet,Blood samples were collected from the vein at certain sampling times. The concentration of omeprazole inplasma was determined by RP-HPLC method and the pharameters were calculated by DAS 2.0 software. Results The main pharmacokinetic parameters of Mongolians were as follows:Cmax was (942.54±297.46)mg·L-1;Tmax was (3.05±1.21)h;t1/2(1.8±1.01)h;AUC0-12 was (2 325.08±1 322.42)mg·h·L-1;AUC0-∞ was (2 381.40±1 355.00)mg·h·L-1。The main pharmacokinetic parameters of Han were as follows:Cmax was (760.49±581.23)mg·L-1;Tmax was (2.70±0.82)h;t1/2 was (1.60±1.28)h;AUC0-12 was (1 437.61±798.05)mg·h·L-1;AUC0-∞ was (1 470.09±769.48)mg·h·L-1.Conclusion Individual difference was significant in Cmax,AUC(0-12),AUC(0-∞) after an oral omeprazole,but the pharmacokinetic parameters obtained from results of ststistic analysis show no significant difference in the main pharmacokinetics of omeprazole between Mongolians and Han.