Pharmacokinetics of omeprazole in Chinese Hui and Han nationalities healthy volunteers after a single dose administration

Objective To study the pharmacokinetics of omeprazole tablets in Chinese Hui and Han healthy volunteers.Methods Twenty volunteers were involved in the study,including ten Chinese Hui volunteers and ten Han volunteers.Each healthy volunlteers were given asingle oral dose(40 mg)of omeprazole tablet.The concentration of omeprazole in plasma was determined by RP-HPLC and the pharameters were calculated by DAS 2.0 software.Results The main pharmacokinetic parameters of Chinese Hui and Han were as follows:Cmax were(941.94±446.08)and(760.49±581.23)μg·L-1;tmax were(2.7±0.68)and(2.70±0.82)h;t1/2 were(2.43±2.83)and(1.60±1.28)h;AUC0-12 were(2.29±1.12)and(1.44±7.98)mg·h·L-1;AUC0-∞ were(2.33±1.11)and(1.47±7.69)mg·h·L-1,respectively.Conclusion Individual difference is significant in Cmax,AUC0-12,AUC0-∞ after an oral omeprazole,but the pharmacokinetic parameters obtained from the results of ststistical analysis show no significant difference in the main pharmacokinetic of omeprazole between Chinese Hui and Han.