Pharmacokinetics of a single dose omeprazole in Chinese Uighur and Han nationalities healthy volunteers

Objective To study the pharmacokinetics of omeprazole tablets after a single oral dose in Uighur and Han healthy volunteers.Methods Twenty volunteers were involved in the study,including ten Uighur volunteers and ten Han volunteers.Each healthy volunteers were given a single oral dose(40 mg)of omeprazole tablet.Blood samples were collected from vein at certain sampling times.The concentration of omeprazole in plasma was determined by HPLC method and the pharmacokinetic parameters were calculated by DAS 2.0 software.Results The main pharmacokinetic parameters of Uighur were as follows:ρmax(728.4±214.3)μg·L-1,tmax(2.8±0.5)h,t1/2(1.2±0.5)h,AUC0-12(1 837.0±861.8)μg·h·L-1,AUC0-∞(1 847.6±869.1)μg·h·L-1.The main pharmacokinetic parameters of Han were as follows:ρmax(760.5±581.2)μg·L-1,tmax(2.7±0.8)h,t1/2(1.6±1.3)h,AUC0-12(1 437.6±798.1)μg·h·L-1,AUC0-∞(1 470.1±769.5)μg·h·L-1.Conclusions Individual difference is significant in ρmax,AUC(0-12),AUC(0-∞)after an oral omeprazole,but the pharmacokinetic parameters obtained from the results of statistical analysis show no significant difference in the main pharmacokinetics of omeprazole between Uighur and Han.