2006•Practical Clinical MedicineRequires access

Effect of Radiation on Cell Cycle of Squamous Cell Carcinoma of Tough

Ming Luo

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Abstract

Objective:To investigate the cell cycle change of squamous cell carcinoma(tca 8113)of tough after radiation.Methods:Radioactive rays-induced cell cycle change were detected by flow cytometry.Results:After irradiation,there was a positive correlation between irradiation dosage and retardation strength in G_2/M phase(P0.01).The peak value appeared at 12 or 24 h after irradiation,then decreased.Cell lines was showed significant S reduce.Conclusion:In the present study,growth delay and enhanced radiosensitivity are confirmed in the progeny of irradiated squamous cell carcinoma cell line of tough tca8113.The cell lines is showed significant S reduce and G_2 arrest.

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Objective:To investigate the cell cycle change of squamous cell carcinoma(tca 8113)of tough after radiation.Methods:Radioactive rays-induced cell cycle change were detected by flow cytometry.Results:After irradiation,there was a positive correlation between irradiation dosage and retardation strength in G_2/M phase(P0.01).The peak value appeared at 12 or 24 h after irradiation,then decreased.Cell lines was showed significant S reduce.Conclusion:In the present study,growth delay and enhanced radiosensitivity are confirmed in the progeny of irradiated squamous cell carcinoma cell line of tough tca8113.The cell lines is showed significant S reduce and G_2 arrest.

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Available abstract

Objective:To investigate the cell cycle change of squamous cell carcinoma(tca 8113)of tough after radiation.Methods:Radioactive rays-induced cell cycle change were detected by flow cytometry.Results:After irradiation,there was a positive correlation between irradiation dosage and retardation strength in G_2/M phase(P0.01).The peak value appeared at 12 or 24 h after irradiation,then decreased.Cell lines was showed significant S reduce.Conclusion:In the present study,growth delay and enhanced radiosensitivity are confirmed in the progeny of irradiated squamous cell carcinoma cell line of tough tca8113.The cell lines is showed significant S reduce and G_2 arrest.

Key concepts: Radiosensitivity, Medicine, Cell cycle, Irradiation, Flow cytometry, Cell culture, Basal cell, Cell

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