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Effect of irradiation with carbon-ion beams on cell cycle after in human squamous cell carcinoma Tb of tough

Hong Zhang

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Abstract

Objective To study the cell cycle alterations in cells of human tounge cancer cell line Tb in vitro after carbon-ion irradiation. Method The cell cycle profile were analyzed by flow cytometry. Results After carbon-ion irradiation,there was a positive correlation between irradiation dosage and retardation strength in G2 /M phase (P0.05). The peak value appeared at 12 h after 0.5,1Gy exposure,and then deceased significantly at 24h.While this release of retardation did not occur after 2.0,4Gy. Conclusion Human squamous cell carcinoma Tb of tough is showed significant G2 / M arrest after carbon ion irradiation.

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Objective To study the cell cycle alterations in cells of human tounge cancer cell line Tb in vitro after carbon-ion irradiation. Method The cell cycle profile were analyzed by flow cytometry. Results After carbon-ion irradiation,there was a positive correlation between irradiation dosage and retardation strength in G2 /M phase (P0.05). The peak value appeared at 12 h after 0.5,1Gy exposure,and then deceased significantly at 24h.While this release of retardation did not occur after 2.0,4Gy. Conclusion Human squamous cell carcinoma Tb of tough is showed significant G2 / M arrest after carbon ion irradiation.

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Available abstract

Objective To study the cell cycle alterations in cells of human tounge cancer cell line Tb in vitro after carbon-ion irradiation. Method The cell cycle profile were analyzed by flow cytometry. Results After carbon-ion irradiation,there was a positive correlation between irradiation dosage and retardation strength in G2 /M phase (P0.05). The peak value appeared at 12 h after 0.5,1Gy exposure,and then deceased significantly at 24h.While this release of retardation did not occur after 2.0,4Gy. Conclusion Human squamous cell carcinoma Tb of tough is showed significant G2 / M arrest after carbon ion irradiation.

Key concepts: Irradiation, Cell cycle, Carbon fibers, Cell, Basal cell, Materials science, Flow cytometry, In vitro

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